Waltham, MA 02451, Orionis Biosciences BV
We are advancing a pipeline of therapeutic agents designed to modulate the Cancer Immunity Cycle through multiple mechanisms and targets. behind the forming of Orionis was that the existing pharmacopeia of approved Allo-Glue™ molecules are a unique class of allosterically acting small molecules that enable access to targets previously thought unapproachable. 950 Winter Street similar drugs.
Orionis has been around since 2015 but kept a low profile over most of that time. The terms of the collaboration include research funding, a convertible note investment, royalties and potential clinical milestones. Our genome-scale data acquisition approach provides a unique foundation for pioneering new numerical methods and machine learning-based approaches to chemical innovation and rational design of small molecules, including Allo-Glue™ molecules. Orionis has developed multiple technology platforms for the discovery of new generations of therapeutics and precision medicines whose pharmacological activities are directed by design to disease targets, avoiding undesired off-target interactions and potentially associated drug liabilities. These drug modalities, which we call Allo-Glue™ small molecules, act as molecular glues to induce formation of protein complexes that can result in target modulation, including inhibition and degradation, of disease-relevant proteins. The result is precise delivery of their biological programming codes to targets such as immune cells, cancer cells and components of tumor or other disease microenvironments. A breakthrough in genome-scale drug discovery.Exploring new dimensions in drug discovery by exploiting the intrinsically flexible and modular nature of proteins. - for patients in need,” commented CEO Niko Kley. Antigen uptake is associated with APC activation (priming), CIC Phase 2
They act to alter the form and function of, and thereby reprogram, intracellular proteins to engage in molecular interactions that modulate disease target proteins, including promoting their degradation by a cell’s natural protein disposal machinery. Our chemical biology platform comprises proprietary technology innovations that uniquely enable high throughput drug ligand screening and mapping of small molecule drug-protein interactions directly in living cells, and at an unprecedented scale and level of complexity. Chemokines released from activated APCs act as chemotactic signals for recruitment of various immune cells (tumor). Our technology platforms further enable access to a broad range of target types to address multiple key disease vulnerabilities for the development of novel therapies. Media Contact:Madeline Davidshoferpress@orionisbio.com781-235-3060, Orionis Biosciences Inc MD, PhD, President of the Novartis Institutes for BioMedical Research commented,
Rationally designed, multifunctional A-Kine™ therapeutics integrate cytokines that are modified to tune out OFF-Target interactions and associated toxicities while simultaneously promoting their own activation at intended target cells (ON-Targets).
A breakthrough in cytokine drug developmentHarnessing the intrinsic functions of cytokines as key regulators of the immune system and natural defense against cancer. Technologiepark 94 9052 Gent, Belgium. This includes cancers that exhibit an intrinsically low or absent immune involvement and thus are particularly challenging therapeutic targets. Waltham, MA 02451, Orionis Biosciences BV Riccardo Sabatini, PhD, CDS, joined Massachusetts-based Orionis Biosciences has flown under the radar since its founding in 2015, has leaped into the mainstream this morning with a major four-year drug discovery collaboration with Swiss pharma giant Novartis. Novartis has entered into a four-year research collaboration with Orionis Biosciences. drug design.”. These include cancer cells, components of tumor microenvironments and various types of immune cells. 950 Winter Street These include cancer cells, components of tumor microenvironments and various types of immune cells. Infiltration. All rights reserved. accomplished over the past several years to develop innovative tools to unlock
The Orionis platform enables large scale interrogation of small molecule targets over a large dynamic range of interaction intensities across up to ~20,000 human proteins, Genome-scale fingerprints provide a unique perspective of drug-target interactions and basis for a new class of numerical methods and chemistry optimization, Orionis Biosciences Inc identifying and prioritizing new targets at a genome-wide scale. The goal of the four-year collaboration with Novartis is to discover and design novel small molecule therapeutics, such as protein degraders, across various therapeutic areas, by broadly leveraging Orionis’ Allo-Glue™ technology platform. at VIB-Ghent University (Belgium), and VIB. In contrast, activity of A-Kine™ biologics is disease target-focused, Illustration of plug-and-play assembly of A-Kine™ biologics with variable types of designer cytokines and cell targeting modules.
Orionis Biosciences is a life sciences company pioneering technological innovation in genome-scale drug discovery and tunable molecular design of novel therapeutic drug modalities. Orionis Biosciences is a life sciences company pioneering technological innovation in genome-scale drug discovery and tunable molecular design of novel therapeutic drug modalities. Technologiepark 94 Our technologies and pipeline include proprietary A-Kine™ biologics and Allo-Glue™ small molecule platforms with broad, innovative applications to the reprogramming of disease states. The agreement tasks Orionis with applying its technologies to “historically elusive targets” in multiple therapeutic areas.
A spectrum of proprietary synergistic approaches is delivering agents that induce potent in vivo antitumor responses in preclinical models, including humanized mice, with observed tumor regressions and induction of cancer immunity. Orionis portfolio includes technologies for genome-scale drug discovery and molecular design of therapeutic modalities, intended to address the most challenging protein targets. Orionis Biosciences is a life sciences company pioneering technological innovation in genome-scale drug discovery and tunable molecular design of novel therapeutic drug modalities. Primed APCs activate and promote proliferation of tumor antigen-speciﬁc T cells (lymph node). All rights reserved. Our technology platforms further enable access to a broad range of target types to … © 2020 Orionis Biosciences. “There are many disease-related targets that have eluded Dr. Jay Bradner,
scientists and drug discoverers for decades, with new ones being identified Allo-Glue™ small molecule can bind to a specific protein and promote target recruitment distal to its binding site in an allosteric manner, Allo-Glue™ molecule complex may also bind to a specific protein and promote target recruitment proximal to its binding site (and directly participate in interaction), Allo-Glue™ molecule-induced interaction can lead to several possible biological effects on target proteins. We are advancing a pipeline of therapeutic agents designed to modulate the Cancer Immunity Cycle through multiple mechanisms and targets. Activated T cells may become memory T cells, which have the potential to impart long term cancer immunity.
Rational design of therapeutic agents targeting fundamental vulnerabilities of human cancers. people, technology platforms and drug modalities. commented Prof. Jan Tavernier. Cancer immunity. CIC Phase 1 Our hope is an array of technological innovations to enable discovery of a diversity of new Our approaches involve the removal of various cancer-imposed brakes on components of the immune system, as well as targeted activation of and enhancement of infiltration of tumors by cancer-inhibitory immune cells, such as cytotoxic T cells (CTLs). drug discovery and development with their innovative technologies for rapidly
an exciting emerging pipeline of drug candidates, which we are advancing to Life sciences firm Orionis Biosciences has partnered with Novartis to discover and design new drugs for the treatment of a variety of diseases. efficiency that is unique in the industry.”. collaboration with Novartis provides tremendous validation of the work we have
CEO of Orionis. Learn more at www.orionisbio.com. To facilitate such cell interaction, we developed an arsenal of compatible cell-targeting modules that can undergo coordinated assembly into A-Kine™ therapeutic agents with applications in cancer and other diseases. Induction of lasting memory T cell responses to promote cancer immunity is our ultimate goal. This may occur distal or proximal to the Allo-Glue™ molecule binding site and may have various effects on disease targets, including their degradation by a cell’s natural protein disposal machinery. - Our proprietary genome-wide discovery and drug design technologies may Waltham, MA 02451, Orionis Biosciences BV 9052 Gent, Belgium. Novartis has entered into a four-year research collaboration with Orionis Biosciences. “Our
Detection, Antigen Presenting Cells (APCs) detect tumor antigens in necrotic tumor mass. targets as we strive to bring new therapies to patients more quickly.”, Riccardo Sabatini Orionis has developed multiple technology platforms for the discovery of new generations of therapeutics and precision medicines whose pharmacological activities are directed by design to disease targets, avoiding undesired off-target interactions and potentially associated drug liabilities.
“We are excited to be working with the Orionis team to combine our expertise in March 5, 2020, Boston (MA, US), Ghent (Belgium) – Orionis Biosciences is today debuting with the announcement of a major drug discovery collaboration with Novartis. Cytokines, such as interferons, tumor necrosis factors and interleukins, are powerful regulators of the immune system and attractive therapeutic effector candidates – provided that their sites of action can be restricted to avoid systemic exposure and toxicity. dimensions in applications of numerical methods and machine learning to support high specificity and selectivity against targets at a scale, speed and unlock major value for the pharmaceutical industry and new treatment options “The opportunity
Activated T cells (CTLs) reach and inﬁltrate tumor through tumor neovasculature. every day. The cytokine has high affinity for its natural receptor expressed on many cell types throughout the human body, Modified cytokine engineered to exhibit low intrinsic affinity and activity towards its natural receptor, Interaction of a modified designer cytokine with its natural receptor on intended target cell is restored upon binding of a linked targeting module to a target cell-specific surface biomarker. Killing.
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